Complete Genomics Showcases More Comprehensive Genome and Transcriptome Analysis with the CoolMPS 600 Sequencer at ASHG 2026  

CoolMPS 600 extends single-end reads to 600 bases to improve analysis of difficult genomic regions while DNBSEQ-T7+ combines 14+ Tb daily output with flexible multi-omics sequencing.

MONTRÉAL, Oct. 20, 2026 – Complete Genomics, a leading innovator in genomic sequencing, is showcasing at the American Society of Human Genetics (ASHG) Annual Meeting expanded sequencing capabilities designed to give researchers greater flexibility across a range of genomic applications. The company is highlighting the longer-read capabilities of the CoolMPS™ 600 sequencer alongside the speed, scale and flexibility of its DNBSEQ T7+ platform. 

CoolMPS chemistry regenerates natural nucleotides during sequencing, an approach designed to reduce the cumulative effects associated with repeated incorporation of labeled nucleotides over longer reads. Combined with DNBSEQ DNA nanoball technology, CoolMPS 600 delivers Q40 accuracy, up to 3.0 Tb (24 40x hWGS) of data per run and independent dual-flow-cell operation, giving labs flexibility across WGS, transcriptomics and other applications.  

For researchers, that means additional options for analyzing difficult regions of the genome, phasing variants, and reconstructing full-length transcripts, while having the capacity to move population-scale and multi-omics projects through the lab quickly.  

Extended read length for challenging genomic regions     

CoolMPS 600 is designed to extend the capabilities of short-read sequencing for applications that benefit from additional read length. Its SE600 kit extends single-end reads to 600 bases while maintaining the throughput and cost advantages of a short-read platform. This is the first MPS/NGS sequencer generating billions of accurate and affordable SE600 reads in a typical run time. The additional read length can help researchers more confidently map through repetitive and otherwise difficult regions, providing additional information for mapping and variant analysis. 

In the highly homologous RHCE region, Complete Genomics data showed that SE600 provided usable, uniquely mapped reads across a 1.9 kb block where PE150 produced only 0.2x uniquely mapped depth. In this analysis, SE600 recovered all 84 truth-set variants in that region.  

The additional read length can also support long-range information in whole-genome sequencing. Complete WGS (cWGS), which will be available via early access next year, combines PCR-free SE600 sequencing with a co-barcoded SE600 stLFR library, delivering both variant calling and long-range phasing from a single workflow. In internal data, 99% of heterozygous SNPs were phased into haplotype blocks of roughly 20 Mb without parental samples, while challenging homologous regions such as SMN1/SMN2 showed improved resolution compared with standard short-read mapping in internal analyses. 

CoolMPS 600 also supports DNBSEQ Complete Transcriptome Set (CTx) that uses co-barcoded SE600 fragments from the same RNA molecule and reference-guided or de novo assembly to reconstruct 1-8 kb full-length transcripts. The approach is designed to provide full-transcript information using a short-read sequencing workflow with its scale and economics. 

 
Pangenome-informed variant calling 

CoLab session at ASHG will show how sequencing chemistry and informatics can work together to improve variant analysis.  

“Pangenome mapping with DeepVariant models trained on Complete Genomics’ CoolMPS 600 chemistry brough errors on the T2T v5 GIAB truth set below 50,000 for HG002, a more than 50% accuracy improvement over linear pipelines, driven largely by how cleanly these reads resolve homopolymers and tandem repeats,” said Andrew Carroll, PhD, product lead for genomics at Google Research. “And because the pipeline is open source and built for scale, any lab can use it.” 

Sentieon, which will give a booth talk at ASHG, has also reported results with its DNAscope Pangenome pipeline on CoolMPS 600 SE600 data, reaching fewer than 30,000 total errors against the T2T v5 truth set. Together, these results from two independent pangenome-aware callers show that CoolMPS 600 data supports substantial accuracy gains across the informatics ecosystem. 

DNBSEQ-T7+: scaling genomics without trading speed for throughput 

Complete Genomics will also highlight DNBSEQ-T7+, its ultra-high-throughput platform for labs running large WGS, population genomics and multi-omics programs. DNBSEQ-T7+ generates more than 14 Tb of data in 24 hours, with four independently controlled flow cells that can run separately or in parallel. That architecture equips labs to combine scale with workload flexibility rather than reserving an entire high-throughput instrument for a single application or batch. 

DNBSEQ-T7+ is designed around three practical priorities for high-volume sequencing operations: speed, simplified workflow and cost efficiency. The system integrates DNB preparation, loading, sequencing, data analysis and compression in a compact automated workflow, while delivering Q40 accuracy and sequencing economics as low as approximately $1 per Gb or $100 per human genome. Its independent flow cells can support mixed workloads spanning WGS, single-cell and spatial transcriptomics. 

“Researchers increasingly need sequencing platforms that can adapt to different scientific questions without adding unnecessary complexity or cost,” said Rade Drmanac, founder and chief scientific officer at Complete Genomics. “CoolMPS 600 gives researchers affordable longer read length at sufficient throughput for advanced applications, while DNBSEQ-T7+ provides the speed and scale needed for ambitious programs. Together, they broaden the range of questions researchers can address with DNBSEQ technology.”  

Complete Genomics will also host presentations featuring leading genomics experts at ASHG 2026: 

• During the CoLab session, Andrew Carroll of Google AI will discuss advances in pangenome-informed, AI-driven variant calling using DeepVariant with DNBSEQ-T7+ and CoolMPS 600 sequencing data.  

• The Industry Workshop will feature Christopher Douville, Ph.D., of Johns Hopkins School of Medicine, discussing genomic and liquid biopsy approaches to cancer research; Alexander Kaplun of Variantyx, sharing clinical validation and implementation experience with DNBSEQ-T7+ for comprehensive whole-genome sequencing; and Michael Snyder, Ph.D., of Stanford University, exploring how longitudinal multi-omics profiling combining genomics, transcriptomics and proteomics can advance personalized medicine.  

Additional presentations at Complete Genomics’ booth will highlight applications in long-read sequencing, AI-powered genomic analysis and single-cell transcriptomics. For a full listing of Complete Genomics programming at ASHG, visit completegenomics.com/events/ashg-2026. 

About Complete Genomics 

Complete Genomics is a pioneering life sciences company providing end-to-end sequencing solutions spanning sample and library preparation, sequencing, automation and data analysis. Its DNBSEQ™ portfolio supports applications from targeted and mid-throughput studies to population-scale genomics and multi-omics research. More than 10,900 scientific publications worldwide are based on DNBSEQ technology. To learn more, visit completegenomics.com. 

*All sequencing products of Complete Genomics on the US market, including CoolMPS 600 and DNBSEQ-T7+ mentioned above, are for research use only and not for any use in diagnostic procedures.

Media Contact: 

Betsy Yates 
Complete Genomics 
byates@completegenomics.com