mapping_alzheimer_disease_spatial_transcriptomics_complete_genomics

In this exciting presentation, Dr. Hui Shen (Tulane Center for Biomedical Informatics and Genomics) showcases how Complete Genomics Stereo-seq, an ultra-high-resolution spatial transcriptomics platform, was used to create the first comprehensive single-nucleus spatial transcriptomic atlas of the human prefrontal cortex in Alzheimer’s disease (AD).

What you’ll learn:

  • Stereo-seq enabled insightful visualizations of disrupted laminar structures, changes in inter-layer communication, and cell-cell interaction networks in AD progression.
  • Discovery of novel AD-related transcriptional regulators like ZNF460, and key neuroprotective genes (VGF, LMO4, NRN1), differentially expressed in early vs. severe AD stages.
  • How APP-CD74 interaction loss and mitochondrial gene proportions signal stressed neuronal regions in a spatially resolved manner.
  • Stereo-seq enables unprecedented resolution to dissect the spatial molecular mechanisms of neurodegeneration by capturing data at the single-nucleus level across distinct cortical layers.

Agenda:

hui-shen-ashg-complete-genomics

Spatial Transcriptomics Analysis of Alzheimer’s Disease Using Stereo-seq

Hui Shen, Professor, Associate Director, Tulane Center for Biomedical Informatics and Genomics

Please fill out the form to access the on-demand webinar.