Letting the Genome Out of the Bottle
Comments on DNA sequencing technology and the coming era of genomic medicine
Updated to clarify information about commercial exome kits
Today, researchers use two approaches to identifying disease-associated variants in the human genome: exome sequencing, which targets the protein-coding regions that make up approximately 1% of the genome, and whole genome sequencing, which investigates the vast majority of the genome and includes both coding and non-coding regions.
Dr. Clifford Reid
Chairman, President and CEO
Dr. Reid is a successful, serial entrepreneur. He enjoys commercializing disruptive computing and life sciences technologies.
Dr. Rade Drmanac
Chief Scientific Officer
Dr. Drmanac is a genome sequencing pioneer; his inventions include massively parallel DNA sequencing by hybridization and combinatorial probe ligation. As a group leader at the Argonne National Labs, he was part of the Human Genome Project. In 1993, he cofounded Hyseq, one of the first genomic companies.